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What sets methylcobalamin apart is its direct involvement in crucial biochemical processes, including the production of neurotransmitters and the regulation of homocysteine levels

Table 4 NcRNAs targets in rheumatoid arthritis

Its defining physicochemical feature is resistance to hydrolysis at low pH, unusual for a peptide of this length and attributed to a proline-rich, conformationally constrained backbone carrying three consecutive prolines plus a fourth at position eight

However, a recent human clinical trial has provided new insights into its potential benefits for chronic pain management

J Mol Neurosci 68:389396